2-Hydroxy-4-methylpyridine CAS 13466-41-6

1. 2-Hydroxy-4-methylpyridine CAS 13466-41-6 is primarily used as a key building block in pharmaceutical development, serving as an intermediate to prepare oxobenzopyrancarboxylate derivatives as inhibitors of serine proteases and human leukocyte elastase .
2. 2-Hydroxy-4-methylpyridine is also utilized in the synthesis of (indanylamino)(pyridinyloxy)pyrazines and analogs as corticotropin releasing factor type-1 receptor antagonists for neuroscience research .
3. 2-Hydroxy-4-methylpyridine has been employed in co-crystal formation studies with active pharmaceutical ingredients like indomethacin, demonstrating significant effects on drug dissolution profiles and intestinal barrier permeability in bioavailability research .
4. Researchers utilize 2-Hydroxy-4-methylpyridine in agricultural chemistry as an intermediate for pesticides and herbicides, and in analytical chemistry as a reagent for chromatographic methods and metal ion detection .

1. 2-Hydroxy-4-methylpyridine CAS 13466-41-6 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light, with recommended storage at room temperature in a cool, dark place below 15°C .
2. 2-Hydroxy-4-methylpyridine is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .
4. Keep away from incompatible materials such as strong oxidizing agents; wash thoroughly after handling, and note that the compound has WGK Germany 3.

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator (type P95 or P1 filter) when 2-Hydroxy-4-methylpyridine CAS 13466-41-6 is released .
2. Collect 2-Hydroxy-4-methylpyridine by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal, avoiding dust generation during cleanup .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as discharge into the environment must be avoided .
4. Dispose of collected 2-Hydroxy-4-methylpyridine material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration with afterburner and scrubber .

1. 2-Hydroxy-4-methylpyridine CAS 13466-41-6 is combustible with a flash point of approximately 170-187°C and NFPA fire rating of 1 (materials requiring considerable preheating before ignition) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 2-Hydroxy-4-methylpyridine may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-Hydroxy-4-methylpyridine due to hazardous decomposition gases generated by thermal decomposition .
4. Hazardous decomposition products formed under fire conditions include toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .