4-Chloroindole CAS 25235-85-2

4-Chloroindole (CAS:25235-85-2) is an important organic raw materials.

Its main applications including:

1. 4-Chloroindole is an important chloro-substituted indole intermediate for antidepressant, antitumor and anti-infective drug synthesis.
2. 4-Chloroindole is a common substrate for Suzuki-Miyaura, Buchwald-Hartwig and other metal-catalyzed coupling reactions.
3. 4-Chloroindole is used to synthesize organic luminescent materials, biological fluorescent probes and fine chemical dye intermediates.

1. Keep airtight packaging and store below 25°C in cool dark warehouse to prevent photooxidation of indole skeleton.
2. Minimize repeated opening of packages to avoid discoloration caused by contact with oxygen.
3. Store separately from strong oxidants, concentrated acids and halogenating agents.

1. Reactive C-Cl bond at the 4-position enables diverse cross-coupling and nucleophilic substitution reactions.
2. Stable indole heterocyclic structure tolerates moderate heating in multi-step organic synthesis.
3. High crystal purity effectively lowers by-product formation in bioactive molecule preparation.

1. Avoid inhaling fine crystalline dust; wear dust mask and chemical-resistant gloves during handling.
2. Do not swallow the solid; rinse splashed eyes and contaminated skin with large amounts of running water instantly.
3. Dispose waste solids and reaction waste liquid following chlorinated aromatic hazardous waste disposal rules.