5-Chloroindole CAS 17422-32-1

5-Chloroindole (CAS:17422-32-1) is an important pharmaceutical intermediate.

Its main applications including:

1. 5-Chloroindole is a key chloro-substituted indole precursor for preparing functionalized indole pharmaceutical intermediates and bioactive compounds.
2. 5-Chloroindole is widely used substrate for metal-catalyzed coupling reactions in fine organic synthesis.
3. 5-Chloroindole is a raw material for synthesizing nitrogen-containing heterocyclic drugs and fine chemical functional products.

1. Seal tightly and store below 25°C in dry dark warehouse to avoid photodegradation and dechlorination of chloro-indole structure.
2. Keep away from impact, friction and high temperature to reduce thermal decomposition risk of aromatic chloro group.
3. Store separately from strong reducing agents, active metals and concentrated strong acids to prevent dechlorination and structural damage.

1. Avoid inhalation of crystalline dust; wear dust mask and chemical-resistant gloves during weighing and transfer.
2. Do not ingest the solid; flush exposed eyes and skin with abundant running water immediately after contact.
3. Dispose waste residues and filtrate strictly following halogenated aromatic hazardous waste management standards.

1. The chloro group acts as a practical reactive site for cross-coupling and nucleophilic substitution to achieve further derivatization of indole derivatives.
2. The indole ring maintains stable structure under normal mild synthesis heating conditions.
3. High purity solid reduces miscellaneous impurities in pharmaceutical intermediate manufacturing routes.