4-Fluoroindole CAS 387-43-9

4-Fluoroindole (CAS:387-43-9) is an important biochemical reagent.

Its main applications including:

1. 4-Fluoroindole is a core fluoro-substituted indole intermediate for synthesis of antitumor, antibacterial and neuropsychiatric drugs.
2. 4-Fluoroindole is widely used substrate for Suzuki coupling, nucleophilic substitution and other fine organic synthesis reactions.
3. 4-Fluoroindole is applied in the preparation of organic optoelectronic materials, biological probes and fluorinated heterocyclic fine chemicals.

1. Keep airtight and store below 25°C in cool dark warehouse to prevent photooxidation and deterioration of indole ring structure.
2. Avoid repeated opening of packaging to prevent air contact-induced discoloration and performance attenuation.
3. Store separately from strong oxidants, concentrated acids and fluorine-sensitive chemical reagents.

1. Avoid inhalation of crystalline dust; wear dust mask and chemical-resistant gloves during weighing and handling.
2. Forbid oral intake; flush contaminated eyes and skin with plenty of running water immediately after accidental exposure.
3. Dispose waste residues and reaction filtrate in accordance with fluorinated aromatic hazardous waste disposal standards.

1. The 4-position fluorine atom provides unique electronic effects and metabolic stability for modified indole derivatives.
2. Stable indole heterocyclic skeleton adapts to various mild heating and catalytic synthesis conditions.
3. High crystal purity effectively reduces impurity by-products in the preparation of high-end pharmaceutical intermediates.