5-Aminolevulinic Acid CAS 106-60-5

1. 5-Aminolevulinic acid is used as a photosensitizing agent in photodynamic therapy (PDT) for the treatment of actinic keratosis and basal cell carcinoma, where it is applied topically and activated by light to destroy abnormal cells .
2. 5-Aminolevulinic acid CAS 106-60-5 serves as a diagnostic tool in fluorescence-guided surgery for high-grade gliomas (brain cancer), where it is administered orally as the "pink drink" (Gliolan) to make malignant tissue fluoresce bright pink under violet light, enabling more complete tumor resection .
3. In antimicrobial research, 5-ALA is employed in antimicrobial photodynamic inactivation (aPDI) to destroy various pathogens including bacteria, fungi, viruses, and yeasts when combined with visible light irradiation .
4. 5-Aminolevulinic acid CAS 106-60-5 functions as a metabolic precursor in heme biosynthesis; it is naturally produced in cells from succinyl-CoA and glycine, and exogenous administration leads to accumulation of protoporphyrin IX (PpIX), particularly in cancer cells due to reduced ferrochelatase activity .

1. 5-Aminolevulinic acid hydrochloride must be stored in a tightly sealed container at -20°C (freezer temperature) to maintain stability; solutions should be prepared immediately before use as the compound undergoes rapid degradation at pH >5.0 and elevated temperatures .
2. 5-Aminolevulinic acid CAS 106-60-5 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves (rubber), chemical safety goggles, and protective clothing when handling this substance; avoid inhalation and contact with skin, eyes, and clothing .
4. Keep away from incompatible materials such as strong oxidizing agents to prevent decomposition. Stock solutions should maintain pH below 5.0 to minimize dimerization to 2,5-dicarboxyethyl-3,6-dihydropyrazine (DHPY), which results in loss of biological activity .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and NIOSH/MSHA-approved respirator when cleaning up 5-aminolevulinic acid .
2. Collect 5-Aminolevulinic acid CAS 106-60-5 by sweeping or vacuuming without creating dust, using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains, sewers, or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical disposal facilities .

1. 5-Aminolevulinic acid is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides .
2. Use 5-Aminolevulinic acid CAS 106-60-5 water spray, carbon dioxide, dry chemical powder, or alcohol-resistant foam to extinguish fires involving the product .
3. Firefighters should wear self-contained breathing apparatus (SCBA) and full protective clothing when handling fires involving this compound due to hazardous decomposition gases generated during thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .