5-Fluoronicotinic Acid CAS 402-66-4

1. 5-Fluoronicotinic acid is a key intermediate in the synthesis of various pharmaceuticals, including the antibiotic enoxacin and other fluoroquinolone-based antibacterial agents .
2. 5-Fluoronicotinic acid CAS 402-66-4 serves as a building block in medicinal chemistry for the preparation of nicotinic acid derivatives with potential anti-inflammatory, anticancer, and neuroprotective activities .
3. 5-Fluoronicotinic acid is employed in organic synthesis as a precursor for the preparation of fluorinated pyridine derivatives, which are valuable in drug discovery and agrochemical development .
4. Researchers utilize 5-Fluoronicotinic acid CAS 402-66-4 as a reference standard in analytical chemistry for the detection and quantification of fluorinated pyridine compounds in pharmaceutical formulations .

1. 5-Fluoronicotinic acid must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; recommended storage at 2-8°C or at -20°C for long-term stability .
2. 5-Fluoronicotinic acid CAS 402-66-4 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas .
4. Keep 5-Fluoronicotinic acid CAS 402-66-4 away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; wash thoroughly after handling .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 5-Fluoronicotinic acid is released .
2. Collect 5-Fluoronicotinic acid CAS 402-66-4 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 5-Fluoronicotinic acid is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen fluoride .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 5-Fluoronicotinic acid CAS 402-66-4 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 5-Fluoronicotinic acid due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .