4-Hydroxyquinazoline CAS 491-36-1

1. 4-Hydroxyquinazoline is a heterocyclic building block used as an intermediate in the synthesis of various pharmaceutical compounds, including antihypertensive, anti-inflammatory, and anticancer agents .
2. 4-Hydroxyquinazoline CAS 491-36-1 serves as a versatile scaffold in medicinal chemistry for the preparation of quinazoline-based kinase inhibitors, such as gefitinib and erlotinib derivatives .
3. 4-Hydroxyquinazoline is employed in the synthesis of antifungal and antimicrobial agents, as well as in the development of herbicides and agrochemicals .
4. Researchers utilize 4-Hydroxyquinazoline CAS 491-36-1 as a precursor for the synthesis of substituted quinazolines, which are important in drug discovery programs targeting various diseases .

1. 4-Hydroxyquinazoline must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; recommended storage at 2-8°C or at -20°C for long-term stability .
2. 4-Hydroxyquinazoline CAS 491-36-1 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; wash thoroughly after handling .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 4-Hydroxyquinazoline is released .
2. Collect 4-Hydroxyquinazoline CAS 491-36-1 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 4-Hydroxyquinazoline is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 4-Hydroxyquinazoline CAS 491-36-1 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 4-Hydroxyquinazoline due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .