Hexamidine Diisocyanate CAS 659-40-5

1. Hexamidine diisocyanate is a cationic antimicrobial agent with broad-spectrum activity against Gram-positive bacteria, Gram-negative bacteria, fungi, and yeasts, primarily used in cosmetic and personal care formulations for anti-dandruff, anti-acne, and preservative functions .
2. In hair care products, Hexamidine diisocyanate is effective against *Malassezia furfur* (the microorganism associated with dandruff), with recommended usage levels of 0.02-0.05% for dandruff control and 0.01-0.02% for itch relief, and it is water-soluble, non-settling, and does not require suspension in formulations .
3. In skin care applications, hexamidine diisocyanate is used in acne treatment products at concentrations of 0.08-0.1%, where it demonstrates efficacy against *Propionibacterium acnes* and inhibits lipase activity, making it particularly suitable for aqueous anti-acne formulations .
4. Hexamidine diisocyanate functions as a broad-spectrum preservative in cosmetic formulations at concentrations of 0.01-0.08%, and is also employed in topical pharmaceutical preparations such as creams, lotions, and eye drops for treating bacterial and fungal infections of the skin, eyes, and mucous membranes .

1. Hexamidine diisocyanate must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at room temperature, protected from light, moisture, and heat sources to prevent degradation .
2. Hexamidine diisocyanate is stable under recommended storage conditions and is classified with WGK Germany 3 (high water hazard potential); UN2811 classification for transport with packing group III applies .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling hexamidine diisocyanate, as Hexamidine diisocyanate is a moderate to severe irritant to skin and eyes .
4. Hexamidine diisocyanate is a cationic substance and is incompatible with anionic ingredients such as xanthan gum, hyaluronic acid, and carbomers, which may cause precipitation or crystallization; the optimal pH range for formulations is 3-8 .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when hexamidine diisocyanate is released .
2. Collect Hexamidine diisocyanate by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses due to potential environmental hazards (WGK Germany 3) .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. Hexamidine diisocyanate is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Hexamidine diisocyanate CAS 659-40-5 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning hexamidine diisocyanate due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .