Cellulose Acetate Phthalate CAS 9004-38-0

1. Cellulose acetate phthalate is a phthalate-containing cellulose derivative primarily used as an enteric coating polymer for pharmaceutical tablets and capsules, protecting acid-labile drugs from gastric degradation and enabling targeted release in the intestine .
2. Cellulose acetate phthalate serves as a film-forming agent and binder in solid dosage formulations, providing excellent moisture barrier properties and compatibility with a wide range of active pharmaceutical ingredients .
3. Cellulose acetate phthalate is employed in controlled-release drug delivery systems, where its pH-dependent solubility (dissolving at pH > 5.5) allows for programmed drug release in the gastrointestinal tract .
4. In pharmaceutical research, cellulose acetate phthalate is used as a carrier for poorly soluble drugs in solid dispersion formulations to enhance dissolution rate and bioavailability .

1. Cellulose acetate phthalate must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; recommended storage at room temperature in a cool, dark place .
2. Cellulose acetate phthalate is classified as non-hazardous under normal handling conditions according to GHS criteria, but may cause mild skin, eye, and respiratory tract irritation .
3. Personnel should wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, avoiding formation of dust and aerosols .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; the compound is stable under recommended storage conditions .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Cellulose acetate phthalate is released .
2. Collect Cellulose acetate phthalate by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations; the substance is considered non-hazardous for transport .

1. Cellulose acetate phthalate is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide and carbon dioxide .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Cellulose acetate phthalate may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Cellulose acetate phthalate due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .