Croscarmellose Sodium CAS 74811-65-7

1. Croscarmellose sodium is a cross-linked polymer of sodium carboxymethylcellulose primarily used as a superdisintegrant in pharmaceutical tablet, capsule, and granule formulations to promote rapid disintegration upon contact with water .
2. Croscarmellose Sodium CAS 74811-65-7 functions by absorbing water and swelling to 4-8 times its original volume, creating a capillary and swelling action that causes the dosage form to break apart and release the active pharmaceutical ingredient .
3. Croscarmellose sodium is suitable for both direct compression and wet granulation tablet manufacturing processes; in wet granulation, Croscarmellose sodium can be added either intragranularly or extragranularly, with extragranular addition typically providing more efficient disintegration .
4. The typical concentration of Croscarmellose sodium in tablet formulations ranges from 0.5% to 5.0% by weight, with concentrations of 2% for direct compression and 3% for wet granulation being commonly used; in capsules, Croscarmellose sodium may be used at concentrations of 10-25% as a disintegrant .

1. Croscarmellose sodium must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, as Croscarmellose sodium is hygroscopic and absorbs moisture from the air .
2. Recommended storage temperature for Croscarmellose sodium is 2-8°C (refrigerated) or at room temperature in a cool, dark place; Croscarmellose sodium is stable for up to three years when stored under appropriate conditions .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling Croscarmellose sodium, as Croscarmellose Sodium CAS 74811-65-7 may cause mild skin and eye irritation .
4. Croscarmellose sodium is incompatible with strong acids, soluble iron salts, and other metals such as aluminum, mercury, and zinc; Croscarmellose sodium should not be used with acidic drugs due to potential chemical interactions .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and a suitable dust respirator when Croscarmellose sodium is released .
2. Collect Croscarmellose Sodium CAS 74811-65-7 by sweeping or vacuuming without creating dust using non-sparking tools, and place Croscarmellose sodium into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with water or appropriate methods .
4. Dispose of collected Croscarmellose sodium according to local, state, and federal environmental regulations; Croscarmellose sodium is considered non-hazardous for transport under normal conditions .

1. Croscarmellose sodium is a combustible solid (Storage Class Code 11) that may decompose under fire conditions, emitting toxic fumes including carbon monoxide and carbon dioxide .
2. Use Croscarmellose Sodium CAS 74811-65-7 water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving Croscarmellose sodium; do NOT use a direct water jet as it may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Croscarmellose sodium due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, Croscarmellose sodium may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination and avoid release into waterways .