5-Aminolevulinic Acid Hydrochloride CAS 5451-09-2

1. 5-Aminolevulinic acid hydrochloride is a natural precursor of heme in the biosynthetic pathway, primarily used as a photosensitizer in photodynamic therapy (PDT) for the treatment of actinic keratosis, basal cell carcinoma, and other superficial skin cancers .
2. 5-Aminolevulinic acid hydrochloride CAS 5451-09-2 is employed as a photosensitizing agent in fluorescence-guided surgery and photodiagnosis for bladder cancer, glioma, and other malignancies, where it induces accumulation of protoporphyrin IX (PpIX) in tumor cells .
3. 5-Aminolevulinic acid hydrochloride serves as a key intermediate in the synthesis of heme, chlorophyll, and vitamin B12, and is used in agricultural research as a biodegradable herbicide and plant growth regulator .
4. Researchers utilize 5-Aminolevulinic acid hydrochloride CAS 5451-09-2 in studies of porphyrin metabolism, heme biosynthesis, and as a tool for investigating mitochondrial function and iron metabolism .

1. 5-Aminolevulinic acid hydrochloride must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; recommended storage at 2-8°C (refrigerated) or at -20°C for long-term stability .
2. 5-Aminolevulinic acid hydrochloride CAS 5451-09-2 is hygroscopic and light-sensitive; powder is stable for up to 3 years at -20°C or 2 years at 4°C, while solutions should be stored at -20°C for up to 1 month or at -80°C for up to 6 months, avoiding repeated freeze-thaw cycles .
3. 5-Aminolevulinic acid hydrochloride is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
4. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 5-Aminolevulinic acid hydrochloride is released .
2. Collect 5-Aminolevulinic acid hydrochloride CAS 5451-09-2 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 5-Aminolevulinic acid hydrochloride is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen chloride .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 5-Aminolevulinic acid hydrochloride CAS 5451-09-2 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 5-Aminolevulinic acid hydrochloride due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .