Di-tert-butylphenylphosphine CAS 32673-25-9

1. Di-tert-Butylphenylphosphine is primarily used as a bulky, electron-rich phosphine ligand in palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura, Negishi, Sonogashira, Stille, Heck, Hiyama, and Buchwald-Hartwig amination reactions .
2. Di-tert-butylphenylphosphine serves as a key reagent for the synthesis of palladium-FiberCats and other catalytic complexes for aryl chloride Suzuki coupling, where its steric bulk (cone angle ~165-170°) and strong electron-donating properties enable efficient activation of challenging aryl chlorides .
3. In pharmaceutical development, Di-tert-butylphenylphosphine acts as an intermediate in the synthesis of bioactive compounds and facilitates the construction of complex molecular architectures required for drug discovery, including antiviral agents such as MK-3682 .
4. The compound is utilized in material science for the production of advanced polymers and nanomaterials with tailored properties, as well as in the development of environmentally friendly chemical processes that reduce waste and improve sustainability .

1. Di-tert-Butylphenylphosphine must be stored in a tightly sealed container under an inert atmosphere (argon or nitrogen) in a cool, dry, well-ventilated area, as the compound is pyrophoric (ignites spontaneously in air) and extremely air-sensitive .
2. Di-tert-butylphenylphosphine is classified with GHS hazard statements H250 (Catches fire spontaneously if exposed to air), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H335 (May cause respiratory irritation), and H413 (May cause long-lasting harmful effects to aquatic life), with signal word "Danger" .
3. Personnel must wear chemical-resistant gloves (nitrile or neoprene), safety goggles with side-shields, flame-resistant protective clothing, and a NIOSH-approved respirator when handling this substance. Operations must be conducted in a fume hood with inert atmosphere .
4. Keep Di-tert-butylphenylphosphine away from incompatible materials including strong oxidizing agents, strong acids, strong bases, and water. The compound reacts violently with water and must be stored away from moisture . Avoid release to the environment due to aquatic toxicity .

1. Isolate the spill area immediately, eliminate all ignition sources, and ensure adequate ventilation. Do NOT allow the spilled material to contact air. Wear full personal protective equipment including flame-resistant clothing, chemical-resistant gloves, safety goggles, and self-contained breathing apparatus .
2. For small spills, carefully cover Di-tert-butylphenylphosphine with an inert absorbent material such as dry sand or vermiculite using non-sparking tools, and place into a suitable closed container under inert atmosphere. For larger spills, use an inert atmosphere containment system .
3. Do NOT allow the product to enter drains, sewers, or water courses. Prevent the spilled material from contacting air or water to avoid spontaneous ignition. Keep away from heat sources and open flames .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical disposal facilities. Contaminated materials must be handled under inert atmosphere and disposed of as pyrophoric hazardous waste .

1. Di-tert-Butylphenylphosphine is a pyrophoric liquid (Category 1) that ignites spontaneously in air. Under fire conditions, the compound decomposes to emit toxic fumes including carbon monoxide, carbon dioxide, and phosphorus oxides .
2. For fires involving this product, use dry sand, dry chemical powder, carbon dioxide, or alcohol-resistant foam. DO NOT use water or a direct water jet, as water may cause violent reactions or scatter burning material .
3. Firefighters must Di-tert-butylphenylphosphine wear self-contained breathing apparatus (SCBA) in pressure-demand, NIOSH-approved, and full flame-resistant protective gear when handling fires involving this compound due to hazardous decomposition gases and the risk of spontaneous ignition .
4. During combustion, may emit irritant and toxic fumes. Contain fire runoff to prevent environmental contamination. For large fires, isolate the area for 800 meters in all directions. Cool unopened containers with water spray from a protected location .