Methyl 3-amino-2-fluorobenzoate CAS 1195768-18-3

1. Methyl 3-amino-2-fluorobenzoate CAS 1195768-18-3 is a fluorinated aromatic building block primarily used in pharmaceutical research for the synthesis of bioactive compounds, including kinase inhibitors and other therapeutic agents .
2. Methyl 3-amino-2-fluorobenzoate serves as a versatile intermediate in medicinal chemistry for the preparation of benzamide and aniline derivatives with potential anticancer, antiviral, and anti-inflammatory activities .
3. In agrochemical development, methyl 3-amino-2-fluorobenzoate is employed as a precursor for the synthesis of herbicides, fungicides, and other crop protection agents .
4. Researchers utilize Methyl 3-amino-2-fluorobenzoate as a building block in organic synthesis, where the amino, fluoro, and ester groups enable selective functionalization through amidation, coupling reactions, and further derivatization .

1. Methyl 3-amino-2-fluorobenzoate must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; recommended storage at 2-8°C or at -20°C for long-term stability .
2. Methyl 3-amino-2-fluorobenzoate is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; wash thoroughly after handling .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when Methyl 3-amino-2-fluorobenzoate is released .
2. Collect Methyl 3-amino-2-fluorobenzoate by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. Methyl 3-amino-2-fluorobenzoate is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen fluoride .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Methyl 3-amino-2-fluorobenzoate may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Methyl 3-amino-2-fluorobenzoate due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .