Protocatechuic Acid CAS 99-50-3

1. Protocatechuic acid CAS 99-50-3 is a natural phenolic acid primarily used in pharmaceutical research for its strong antioxidant, anti-inflammatory, and neuroprotective properties, with studies showing potential for wound tissue regeneration and relieving oxidative stress .
2. Protocatechuic acid exhibits diverse biological activities including antimicrobial, anti-cancer, anti-hyperglycemic, and cardiovascular protective effects, and serves as a metabolite of complex polyphenols like anthocyanins .
3. Protocatechuic acid is employed in food industry applications as a natural preservative with antioxidant and antibacterial abilities to extend shelf life, and in cosmetics as an active ingredient for anti-aging and whitening products .
4. Researchers utilize Protocatechuic acid in agricultural applications as a natural plant protectant, and derivatives such as its methyl ester have demonstrated antifungal activity against postharvest pathogens like *Botrytis cinerea* in strawberries .

1. Protocatechuic acid CAS 99-50-3 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at 2-8°C or -20°C for long-term stability, protected from light and moisture .
2. Protocatechuic acid is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .
4. Keep Protocatechuic acid away from incompatible materials such as strong oxidizing agents and strong bases to prevent decomposition; for solution storage, prepare aliquots and avoid repeated freeze-thaw cycles .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when protocatechuic acid CAS 99-50-3 is released .
2. Collect Protocatechuic acid by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal, avoiding dust generation .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as discharge into the environment must be avoided.
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. Protocatechuic acid CAS 99-50-3 has a melting point of 197-200°C (dec.) and boiling point of 410.7°C at 760 mmHg; under fire conditions, hazardous decomposition products include toxic fumes of carbon monoxide and carbon dioxide .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Protocatechuic acid may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning protocatechuic acid due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .