Shikimic Acid CAS 138-59-0

1. Shikimic acid CAS 138-59-0 is a natural organic compound and key biochemical intermediate in the shikimate pathway, which is essential for the biosynthesis of aromatic amino acids (phenylalanine, tyrosine, tryptophan) in plants and microorganisms .
2. Shikimic acid is primarily used as a starting material for the industrial synthesis of the antiviral drug oseltamivir phosphate (Tamiflu®), which is crucial for treating and preventing influenza A and B infections .
3. Shikimic acid serves as a valuable chiral building block in organic synthesis for producing various bioactive compounds, including enzyme inhibitors, antibiotics, herbicides, and other pharmaceutical intermediates .
4. Researchers utilize Shikimic acid in studies of plant metabolism, as a standard in analytical chemistry, and in the development of new drugs targeting microbial and viral pathogens through disruption of the shikimate pathway .

1. Shikimic acid CAS 138-59-0 must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light; recommended storage at 2-8°C or at -20°C for long-term stability .
2. Shikimic acid is generally not classified as a hazardous substance under GHS criteria, but may cause eye, skin, and respiratory irritation ; some sources classify it with hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) .
3. Personnel should wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, avoiding formation of dust and aerosols, and working in well-ventilated areas .
4. Keep Shikimic acid away from incompatible materials such as strong oxidizing agents and strong bases ; for solution storage, prepare aliquots in tightly sealed vials and use within recommended timeframes to prevent degradation .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves and safety goggles when shikimic acid is released .
2. Collect Shikimic acid by sweeping or vacuuming without creating dust using non-sparking tools, or absorb with inert materials such as diatomite or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; no special environmental precautions are required, but discharge into drains should be prevented .
4. Dispose of collected Shikimic acid material according to local, state, and federal environmental regulations, offering surplus and non-recyclable solutions to a licensed disposal company .

1. Shikimic acid CAS 138-59-0 is not classified as highly flammable with NFPA fire rating of 1 (materials that require considerable preheating before ignition); under fire conditions, hazardous decomposition products include toxic fumes of carbon monoxide, carbon dioxide, and irritating gases .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as Shikimic acid may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning shikimic acid due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination .