1-Chloroethyl Chloroformate CAS 50893-53-3

1. 1-Chloroethyl chloroformate CAS 50893-53-3 is a specialized reagent primarily used for the N-demethylation of tertiary amines, a key reaction in organic synthesis to produce secondary amine metabolites, particularly for pharmaceutical and forensic toxicological applications .
2. 1-Chloroethyl chloroformate serves as a versatile electrophilic building block to introduce the α-chloroethyl group into molecules and is employed in the synthesis of various pharmaceuticals and agrochemicals .
3. Applications of 1-Chloroethyl chloroformate also include its use as a mild and efficient reagent for removing benzyl protecting groups and for the functionalization of alcohols or amines to form carbamate derivatives .

1. Store 1-Chloroethyl chloroformate CAS 50893-53-3 in a tightly sealed container under an inert atmosphere in a cool, dry, and well-ventilated place, protected from moisture as it is moisture sensitive and reacts with water . Recommended long-term storage is at 2-8°C (refrigerated) .
2. Keep 1-Chloroethyl chloroformate away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents, strong bases, and alcohols .
3. Always 1-Chloroethyl chloroformate use appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles, face shield, and protective clothing. Handle only in a chemical fume hood with explosion-proof equipment to avoid breathing vapors, mist, or gas .

1. Immediately isolate the spill area (at least 50 meters in all directions), eliminate all ignition sources, and provide adequate ventilation. Contain 1-Chloroethyl chloroformate CAS 50893-53-3 using dry, inert, non-combustible absorbent material (e.g., dry sand) and absolutely avoid contact with water .
2. Carefully collect 1-Chloroethyl chloroformate using non-sparking tools (or an explosion-proof vacuum) into a sealed, corrosion-resistant chemical waste container for proper disposal according to local, state, and federal environmental regulations. Do not let the product enter drains or waterways .
3. Personnel must wear full chemical-protective equipment including positive pressure self-contained breathing apparatus (SCBA) during cleanup. 1-Chloroethyl chloroformate is classified for transport.

1. 1-Chloroethyl chloroformate CAS 50893-53-3 is classified as a highly hazardous substance (GHS signal word "Danger") with acute toxicity: toxic by inhalation (H330/H331), harmful if swallowed (H302), and causes severe skin burns and serious eye damage (H314/H318) . It is also a flammable liquid (H226) with a flash point of 40-45°C (105°F) .
2. 1-Chloroethyl chloroformate is moisture sensitive and reacts violently with water, releasing toxic and corrosive gases including hydrogen chloride. It is a lachrymator (tear gas agent) and causes burns to skin, eyes, and mucous membranes . Thermal decomposition produces toxic fumes including phosgene and carbon oxides.
3. Always 1-Chloroethyl chloroformate CAS 50893-53-3 consult the specific Safety Data Sheet (SDS) for 1-Chloroethyl chloroformate for complete hazard information, first-aid procedures, and mandatory handling protocols .