2-Bromobenzonitrile CAS 2042-37-7

1. 2-Bromobenzonitrile is primarily used as a versatile building block in organic synthesis for pharmaceuticals, agrochemicals, and functional materials. Its reactivity is due to the electron-deficient aromatic system from the nitrile group, which facilitates both nucleophilic aromatic substitution and cross-coupling reactions like Suzuki-Miyaura couplings.
2. The compound serves as a key intermediate in medicinal chemistry for synthesizing bioactive molecules, including precursors to hypertension drugs (e.g., o-tolyl benzonitrile), antiretroviral agents, and potential anti-Alzheimer or anti-Parkinson agents. 2-Bromobenzonitrile CAS 2042-37-7 is also used as a starting material for novel benzothiophene derivatives with antibacterial and antifungal activity.
3. Applications of 2-Bromobenzonitrile also include its role in photoredox dehalogenation reactions and as a reagent in reactions requiring an electron-rich species for nucleophilic substitution (or addition) reactions.

1. Store 2-Bromobenzonitrile in a tightly sealed container in a cool, dry, well-ventilated area away from incompatible substances. Recommended storage is below +30°C or at ambient temperatures, protected from light and moisture.
2. Keep 2-Bromobenzonitrile away from strong oxidizing agents, strong acids, and strong bases to prevent hazardous decomposition. It is stable under normal storage and handling conditions.
3. Always use 2-Bromobenzonitrile CAS 2042-37-7 appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing. Avoid dust formation and ensure adequate ventilation or use in a fume hood when handling 2-Bromobenzonitrile.

1. Immediately isolate the spill area and ensure adequate ventilation; contain 2-Bromobenzonitrile using inert, non-combustible absorbent material (e.g., sand) and avoid generating dust.
2. Carefully sweep up the spilled 2-Bromobenzonitrile using clean, non-sparking tools, and place the collected material into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations.
3. Personnel 2-Bromobenzonitrile CAS 2042-37-7 must wear suitable PPE including self-contained breathing apparatus (SCBA) if necessary during cleanup; prevent material from entering drains or waterways. 2-Bromobenzonitrile is classified for transport (UN3439, Hazard Class 6.1, PG III).

1. 2-Bromobenzonitrile is classified with GHS signal word "Warning". It is harmful if swallowed (H302), harmful in contact with skin (H312), and causes skin irritation (H315), serious eye irritation (H319), and respiratory irritation (H335). Some classifications also include H331 (toxic if inhaled).
2. 2-Bromobenzonitrile is combustible with a flash point >110°C (230°F). Its thermal decomposition or combustion can produce toxic and irritating fumes including carbon oxides, nitrogen oxides, and hydrogen bromide. 2-Bromobenzonitrile CAS 2042-37-7 is harmful to aquatic life with long-lasting effects (H412) and has a WGK Germany rating of 2 (water hazard).
3. Always consult the specific Safety Data Sheet (SDS) for 2-Bromobenzonitrile for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P302+P352 for skin, P304+P340 for inhalation), and handling instructions. Precautionary statements include P261 (avoid breathing dust), P280 (wear protective gloves/eye protection), and P405 (store locked up).