2-Phenylacetophenone CAS 451-40-1

1. 2-Phenylacetophenone is a benzoin derivative used as a photoinitiator in vinyl polymerization .
2. 2-Phenylacetophenone CAS 451-40-1 has broad-spectrum efflux pump inhibition activity, displaying antibacterial effects against strains like *B. subtilis* and *M. smegmatis* with MICs of 500 µg/mL and inhibition of biofilm formation .
3. Applications of 2-Phenylacetophenone include its use as an intermediate in organic synthesis, such as for the production of the pharmaceutical tamoxifen .

1. Store 2-Phenylacetophenone in a tightly sealed container in a cool, dry, and well-ventilated place, protected from light and incompatible materials like strong acids/alkalis and strong oxidizing/reducing agents . Recommended storage temperature is 2-8°C (refrigerated) ; long-term storage for powder is -20°C (3 years) or 4°C (2 years) .
2. Keep 2-Phenylacetophenone away from strong oxidizing agents, strong acids, and strong alkalis to prevent decomposition or hazardous reactions . Avoid dust formation and ensure adequate ventilation .
3. Always use 2-Phenylacetophenone CAS 451-40-1 appropriate personal protective equipment (PPE) including chemical-resistant gloves (impervious), safety goggles with side-shields, and protective clothing; avoid inhalation and contact with eyes and skin .

1. Immediately isolate the spill area, avoid dust formation, and ensure adequate ventilation. Contain 2-Phenylacetophenone using dry, inert, non-combustible absorbent material (e.g., diatomite, universal binders) and prevent entry into drains or waterways .
2. Carefully sweep up the spilled 2-Phenylacetophenone solid using clean methods and place the collected material into sealed, labeled chemical waste containers for proper disposal according to local, state, and federal environmental regulations . Decontaminate surfaces with alcohol .
3. Personnel must 2-Phenylacetophenone CAS 451-40-1 wear suitable PPE, including self-contained breathing apparatus if necessary, during cleanup . 2-Phenylacetophenone is not classified as hazardous goods for transport by some regulations (DOT, IMDG, IATA, ADR/RID) .

1. 2-Phenylacetophenone is not classified as a hazardous substance or mixture according to GHS by some suppliers (signal word: none), with a "Warning" signal word assigned by others . It causes skin and eye irritation upon contact , and inhalation may cause respiratory tract irritation . Safety phrases include S22 (do not breathe dust) and S24/25 (avoid contact with skin and eyes) .
2. 2-Phenylacetophenone has a flash point of 110-137°C (230-279°F) and is combustible . Under fire conditions, thermal decomposition produces toxic and irritating fumes including carbon oxides . It is stable under recommended storage conditions . LD50 intravenous (mouse) is 320 mg/kg .
3. Always consult 2-Phenylacetophenone CAS 451-40-1 the specific Safety Data Sheet (SDS) for 2-Phenylacetophenone for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P302+P352 for skin, P301+P312+P330 for ingestion), and handling instructions .