Methacryloyl Chloride CAS 920-46-7

1. Methacryloyl chloride is a versatile monomer and intermediate primarily used to synthesize methacrylate-based polymers, resins, adhesives, and coatings for industries including electronics, construction, and automotive .
2. Methacryloyl chloride CAS 920-46-7 is employed as a crosslinking agent and for surface modification in biomedical applications, including the production of hydrogels for contact lenses and bioconjugation for targeted drug delivery .
3. Applications of Methacryloyl chloride also include its use in manufacturing pharmaceuticals, cosmetics, and as a reactive building block for introducing methacrylate functionality into various compounds via reactions with alcohols and amines .

1. Store Methacryloyl chloride in a tightly sealed container under inert gas (argon/nitrogen) in a cool, dry, well-ventilated place; recommended storage temperatures range from 2-8°C to below +30°C, and it must be protected from moisture as it hydrolyzes in water .
2. Keep Methacryloyl chloride strictly away from heat, sparks, open flames, strong oxidizing agents, and strong bases due to its high flammability and reactivity; containers and receiving equipment must be grounded/bonded to prevent electrostatic discharge .
3. Always use Methacryloyl chloride CAS 920-46-7 appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles with faceshield, and fire-resistant protective clothing; handle only with explosion-proof equipment in a fume hood to avoid breathing vapors .

1. Immediately isolate the spill area (minimum 50 meters/150 feet), eliminate all ignition sources, and evacuate non-essential personnel; contain Methacryloyl chloride using dry, inert, non-combustible absorbent material (e.g., dry sand) and DO NOT use water .
2. Carefully collect Methacryloyl chloride CAS 920-46-7 using non-sparking, explosion-proof tools into sealed, labeled corrosion-resistant chemical waste containers; prevent entry into drains or waterways .
3. Personnel must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup; Methacryloyl chloride is classified for transport (UN3383, Hazard Class 6.1/3, PG I) and requires hazardous waste disposal according to all environmental regulations .

1. Methacryloyl chloride is classified as a highly flammable liquid and vapor (H225) and is fatal if inhaled (H330, Category 1) with a rat LC50 of 14 ppm/4hrs; Methacryloyl chloride CAS 920-46-7 causes severe skin burns and serious eye damage (H314/H318) .
2. Methacryloyl chloride is harmful if swallowed (H302, Category 4), may cause an allergic skin reaction (H317), and is harmful to aquatic life with long-lasting effects (H412); Methacryloyl chloride CAS 920-46-7 reacts violently with water, releasing toxic and corrosive hydrogen chloride gas .
3. Always consult the specific Safety Data Sheet (SDS) for Methacryloyl chloride for complete hazard information, first-aid procedures (P303+P361+P353 for skin, P305+P351+P338 for eyes, P304+P340+P310 for inhalation), and handling instructions. Precautionary statements include P210 (keep away from heat/sparks/open flames), P233 (keep container tightly closed), P260 (do not breathe vapors), P273 (avoid release to environment), P280 (wear protective gloves/eye protection), and P310 (immediately call a poison center/doctor) .