Methanesulfonamide CAS 3144-09-0

1. Methanesulfonamide is primarily used as a key intermediate in the production of pharmaceuticals and agrochemicals . For instance, it serves as an intermediate in the synthesis of the herbicide fomesafen .
2. Methanesulfonamide CAS 3144-09-0 is a valuable building block in medicinal chemistry for synthesizing biologically active molecules, including those with antitumor, anti-inflammatory, and COX-2 inhibitory activities . The methanesulfonamide group is also a structural feature in some drug molecules, such as the antiviral agent dasabuvir .
3. Applications of Methanesulfonamide also include its use as a reagent in organic synthesis for introducing the methanesulfonamide functional group into target compounds .

1. Store Methanesulfonamide in a tightly sealed container in a cool, dry, and well-ventilated place. It is recommended to keep it in a dark place, protected from light and moisture, at room temperature .
2. Keep Methanesulfonamide away from strong oxidizing agents and strong bases, as it is incompatible with these materials and may cause hazardous decomposition .
3. Always use Methanesulfonamide CAS 3144-09-0 appropriate personal protective equipment (PPE), including chemical-resistant gloves and safety goggles, when handling Methanesulfonamide to avoid skin, eye, and respiratory contact. Wash thoroughly after handling .

1. Immediately isolate the spill area and ensure adequate ventilation. Contain Methanesulfonamide using inert, non-combustible absorbent material (e.g., dry sand) and prevent entry into drains or waterways .
2. Carefully sweep up the spilled Methanesulfonamide solid using a clean, non-sparking tool and place it into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel Methanesulfonamide CAS 3144-09-0 must wear suitable PPE during cleanup. Under fire conditions, irritating and highly toxic gases may be generated during combustion or thermal decomposition .

1. Methanesulfonamide is classified as harmful if swallowed (H302) . It causes skin irritation (H315) and serious eye irritation (H319) . The GHS signal word is "Warning" .
2. Methanesulfonamide is stable under normal temperatures and pressures. Hazardous decomposition products from combustion or thermal decomposition include nitrogen oxides, carbon monoxide, and other irritating and toxic fumes . The compound has a melting point range of 85-94 °C .
3. Always consult Methanesulfonamide CAS 3144-09-0 the specific Safety Data Sheet (SDS) for Methanesulfonamide for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P301+P312+P330 for ingestion), and handling instructions. Precautionary statements include P264 (wash skin thoroughly after handling) and P280 (wear protective gloves/eye protection) .