Chloroacetyl Chloride CAS 79-04-9

1. Chloroacetyl chloride is a highly reactive bifunctional compound used as a critical building block in organic synthesis for producing herbicides (e.g., metolachlor, alachlor) and pharmaceutical intermediates (e.g., Diazepam, Diclofenac) . It serves as both an acylating and alkylating agent.
2. Chloroacetyl chloride CAS 79-04-9 is extensively employed in medicinal chemistry for manufacturing active pharmaceutical ingredients (APIs), including rare-earth element chelators like DOTA and NOTA for diagnostic imaging, and as an intermediate in peptide synthesis for side-chain protection .
3. Applications of Chloroacetyl chloride also include its use as a key intermediate in the synthesis of cephalosporin antibiotics like cefathiamidine, where it reacts with 7-ACA to form chloroacetyl 7-ACA .

1. Store Chloroacetyl chloride in a tightly sealed container under an inert atmosphere (nitrogen) in a cool, dry, well-ventilated area, protected from moisture as it readily hydrolyzes . Shelf life under proper conditions is approximately 8 months .
2. Keep Chloroacetyl chloride strictly away from water, strong oxidizing agents, and strong bases; contact with water liberates toxic gas and the hydrolysis product can react with metals to produce flammable hydrogen gas .
3. Always Chloroacetyl chloride CAS 79-04-9 use appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles with faceshield, and full protective clothing; handle only in a chemical fume hood with explosion-proof equipment as it is a lachrymator and highly corrosive .

1. Immediately evacuate the area, isolate the spill (100-300 ft depending on size), and ensure adequate ventilation; for spills on land, contain Chloroacetyl chloride using dry, inert, non-combustible absorbent material (dry lime, soda ash, sand) and absolutely avoid contact with water .
2. Carefully collect Chloroacetyl chloride CAS 79-04-9 using non-sparking tools into sealed, corrosion-resistant chemical waste containers for proper disposal; for spills in water, large amounts of toxic hydrogen chloride (HCl) gas may be produced .
3. Personnel must wear full chemical-protective equipment including gas-tight suit and self-contained breathing apparatus (SCBA) during cleanup; Chloroacetyl chloride is classified for transport (UN1752, Hazard Class 6.1/8, PG I, Inhalation Hazard Zone B) .

1. Chloroacetyl chloride is classified with GHS signal word "Danger" and is toxic if swallowed (H301), in contact with skin (H311), or if inhaled (H331). It causes severe skin burns and serious eye damage (H314/H318) and is a known lachrymator .
2. Chloroacetyl chloride is corrosive, reacts violently with water releasing toxic and corrosive gases (hydrogen chloride), and may cause damage to organs through prolonged or repeated exposure (H372). It is toxic to aquatic life with long-lasting effects (H400) and has a flash point of 100°C .
3. Always Chloroacetyl chloride CAS 79-04-9 consult the specific Safety Data Sheet (SDS) for Chloroacetyl chloride for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P303+P361+P353 for skin, P301+P330+P331 for ingestion, P304+P340 for inhalation), and handling instructions. Precautionary statements include P260 (do not breathe vapors), P280 (wear protective gloves/eye protection), and P405 (store locked up) .