Ellagic Acid CAS 476-66-4

1. Ellagic acid is a naturally occurring polyphenol with potent antioxidant, anti-inflammatory, and neuroprotective properties, making it a focal point in pharmacological research for treating neurodegenerative diseases like Alzheimer's and Parkinson's . It acts by scavenging free radicals, enhancing antioxidant defenses, and reducing neuroinflammation .
2. Ellagic acid CAS 476-66-4 demonstrates significant anticancer potential, notably as an inhibitor of EZH2 (Enhancer of Zeste homolog 2), an epigenetic regulator implicated in cancer progression. Studies show Ellagic acid binds to EZH2, reducing tumor growth and inducing apoptosis in cancer cells, with promising results in breast cancer models .
3. Applications of Ellagic acid also include its use in treating metabolic disorders, as an adjuvant to reduce side effects of chemotherapy drugs like cisplatin, and in the cosmetic industry for its anti-aging effects .

1. Store Ellagic acid in a tightly sealed container under inert gas (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place, protected from light and air, as Ellagic acid CAS 476-66-4 is air and light sensitive . Recommended storage temperatures vary: powder can be stored at -20°C for up to 3 years or at 4°C for 2 years; solutions should be stored at -80°C for 6 months or -20°C for 1 month .
2. Keep Ellagic acid away from strong oxidizing agents, strong acids, and strong alkalis to prevent decomposition . It is incompatible with these materials and should be protected from moisture .
3. Always use appropriate personal protective equipment (PPE) including chemical-resistant gloves (nitrile, minimum 0.11 mm thickness), safety goggles, and protective clothing; avoid dust formation and ensure adequate ventilation when handling Ellagic acid .

1. Immediately isolate the spill area and ensure adequate ventilation; contain Ellagic acid using inert, non-combustible absorbent material (e.g., diatomite, universal binders) and avoid generating dust .
2. Carefully sweep up the spilled Ellagic acid using clean, non-sparking tools, and place the collected material into a sealed, labeled chemical waste container for proper disposal according to local, state, and federal environmental regulations .
3. Personnel Ellagic acid CAS 476-66-4 must wear suitable PPE during cleanup; prevent material from entering drains or waterways. Decontaminate surfaces and equipment by scrubbing with alcohol .

1. Ellagic acid is classified with GHS signal word "Warning" by some authorities but as "Not a hazardous substance" by others . It is harmful if swallowed (H302) , causes skin irritation (H315), serious eye irritation (H319), and may cause respiratory irritation (H335) . The NFPA health rating is 2 (moderate hazard) .
2. Ellagic acid is combustible with a melting point >360°C . Ellagic acid CAS 476-66-4 is practically insoluble in water but soluble in DMSO (up to 3 mg/mL) and alkaline solutions like 1 M NaOH . Its thermal decomposition or combustion produces toxic and irritating fumes including carbon oxides . Acute oral LD50 (rat) is >20,000 mg/kg .
3. Always Ellagic acid CAS 476-66-4 consult the specific Safety Data Sheet (SDS) for Ellagic acid for complete hazard information, first-aid procedures (P305+P351+P338 for eyes, P301+P330+P331 for ingestion, P304+P340 for inhalation), and handling instructions .