Dimethyl Fumarate CAS 624-49-7

1. Dimethyl fumarate  CAS 624-49-7is an FDA-approved immunomodulatory drug used for the treatment of relapsing forms of multiple sclerosis and plaque psoriasis . Its mechanism of action involves activating the Nrf2 antioxidant pathway and modulating inflammatory pathways like NF-kB .
2. Dimethyl fumarate is also a subject of ongoing research for new therapeutic uses, including its potential to inhibit pathological angiogenesis in eye diseases like neovascular age-related macular degeneration (nAMD) and to slow the progression of geographic atrophy (GA) in dry AMD .
3. In addition to its pharmaceutical roles, Dimethyl fumarate is used in organic synthesis as a dienophile in Diels-Alder reactions and for cycloadditions . Historically, it has also been employed as an antifungal agent in the preservation of furniture, textiles, and stored goods, though this use is restricted in some regions .

1. Store Dimethyl fumarate CAS 624-49-7 in a tightly sealed container in a cool, dry, and well-ventilated place, protected from light. Recommended storage temperatures vary from room temperature (in a cool, dark place) to -20°C for long-term stability, depending on the product form and source . It is stable for up to 4 years under recommended conditions .
2. Keep Dimethyl fumarate strictly away from strong oxidizing agents, reducing agents, strong acids, and strong bases due to incompatibility . It should also be protected from moisture.
3. Always use Dimethyl fumarate appropriate personal protective equipment (PPE) including chemical-resistant gloves (nitrile rubber recommended), safety goggles, and protective clothing to avoid skin, eye, and respiratory contact . Avoid generating dust and handle only with adequate ventilation .

1. Immediately isolate the spill area and ensure adequate ventilation. Contain Dimethyl fumarate CAS 624-49-7 using dry, inert, non-combustible absorbent material (e.g., dry sand) and prevent entry into drains or waterways .
2. Carefully sweep up Dimethyl fumarate using clean, non-sparking tools without creating dust, and place the collected material into sealed, labeled chemical waste containers for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear suitable PPE including chemical-resistant gloves and eye protection during cleanup . Dimethyl fumarate is not classified as dangerous goods for transport by some regulations.

1. Dimethyl fumarate CAS 624-49-7 is classified with a GHS signal word "Warning". It is harmful if swallowed (H302), in contact with skin (H312), or if inhaled (H332). It causes skin irritation (H315) and serious eye irritation (H319), and may cause an allergic skin reaction (H317) . Acute toxicity data shows LD50 dermal (rabbit) of 1,250 mg/kg .
2. Dimethyl fumarate has a flash point of 91-93°C and is combustible . Its thermal decomposition or combustion produces toxic and irritating fumes, including carbon monoxide . It is toxic to aquatic life with long-lasting effects (H411) and should not be released into the environment .
3. Always consult Dimethyl fumarate the specific Safety Data Sheet (SDS) for Dimethyl fumarate for complete hazard information, first-aid procedures , and handling instructions. Precautionary statements include P261 (avoid breathing dust), P273 (avoid release to environment), P280 (wear protective gloves/eye protection), and P405 (store locked up) .