Ethyl Bromodifluoroacetate CAS 667-27-6

1. Ethyl bromodifluoroacetate CAS 667-27-6 is widely used as a versatile fluorinated building block in organic synthesis, serving as a key reagent in Reformatsky reactions to synthesize difluoro-beta-lactams and 2,2-difluoro-3-hydroxy esters .
2. The compound acts as an efficient difluorocarbene precursor for the direct conversion of primary amides to nitriles under mild, metal-free conditions . Ethyl bromodifluoroacetate can also be employed as a C1 source in copper-catalyzed carbocyclization reactions to synthesize N-containing heterocyclics .
3. Ethyl bromodifluoroacetate functions as a bifunctional reagent in copper-catalyzed selective C5-H functionalization of 8-aminoquinoline amides, enabling both bromination and difluoromethylation reactions depending on catalyst selection . It is also used in the synthesis of gallic acid derivatives exhibiting plant growth promoting activity .

1. Store Ethyl bromodifluoroacetate CAS 667-27-6 in a tightly sealed container under an inert atmosphere in a cool, dry, well-ventilated place, away from heat, sparks, and open flames. Recommended storage temperatures range from room temperature (in a cool, dark place) to -20°C for long-term stability of solutions .
2. Keep Ethyl bromodifluoroacetate strictly away from strong oxidizing agents due to incompatibility. Containers and receiving equipment must be grounded/bonded to prevent electrostatic discharge, as vapors may form explosive mixtures with air .
3. Always use Ethyl bromodifluoroacetate appropriate personal protective equipment (PPE) including chemical-resistant gloves, tightly fitting safety goggles with faceshield, and flame-retardant antistatic protective clothing. Handle only with explosion-proof equipment in a fume hood to avoid breathing vapors, mist, or gas .

1. Immediately isolate the spill area (minimum 50 meters), eliminate all ignition sources, and evacuate non-essential personnel. Contain Ethyl bromodifluoroacetate CAS 667-27-6 using dry, inert, non-combustible absorbent material (e.g., dry sand) and prevent entry into drains or waterways .
2. Carefully collect Ethyl bromodifluoroacetate using non-sparking, explosion-proof tools (or an electrically protected vacuum cleaner/wet-brushing) into sealed, labeled chemical waste containers for proper disposal according to local, state, and federal environmental regulations .
3. Personnel must wear full chemical-protective equipment including self-contained breathing apparatus (SCBA) during cleanup. A vapor-suppressing foam may be used to reduce vapors. Ethyl bromodifluoroacetate is classified for transport (UN3272 or UN2924, Hazard Class 3, PG II) .

1. Ethyl bromodifluoroacetate is classified as a highly flammable liquid and vapor (H225, Danger) with a flash point of 21°C (70°F). It is corrosive, causing severe skin burns and serious eye damage (H314/H318). The NFPA health rating is 3 (serious hazard), flammability 3, and reactivity 0 .
2. Thermal decomposition or combustion of Ethyl bromodifluoroacetate produces toxic and corrosive fumes including carbon oxides, hydrogen bromide gas, and hydrogen fluoride . It is soluble in most organic solvents and has a boiling point of 112°C, density of 1.583 g/mL at 25°C .
3. Always consult Ethyl bromodifluoroacetate the specific Safety Data Sheet (SDS) for Ethyl bromodifluoroacetate for complete hazard information and first-aid procedures. Precautionary statements include P210 (keep away from heat/sparks/open flames), P233 (keep container tightly closed), P240 (ground/bond container), and P280 (wear protective gloves/eye protection) .