1 2-Bis(bromomethyl)benzene CAS 91-13-4

1. 1,2-Bis(bromomethyl)benzene CAS 91-13-4 is a versatile alkylating agent and crosslinking reagent used in organic synthesis for the preparation of macrocycles, crown ethers, and polycyclic compounds via nucleophilic substitution reactions .
2. 1 2-Bis(bromomethyl)benzene serves as a key intermediate in the synthesis of functionalized materials, including metal-organic frameworks (MOFs), covalent organic frameworks (COFs), and other supramolecular architectures .
3. 1,2-Bis(bromomethyl)benzene is employed in the synthesis of pharmaceuticals and agrochemicals, where its benzylic bromine atoms enable selective functionalization for constructing complex molecular scaffolds .
4. Researchers utilize 1 2-Bis(bromomethyl)benzene as a building block for the preparation of phosphine ligands, phase transfer catalysts, and as a precursor for the synthesis of xylene-based polymers and resins .

1. 1,2-Bis(bromomethyl)benzene must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; recommended storage at 2-8°C or at -20°C for long-term stability .
2. 1 2-Bis(bromomethyl)benzene is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas .
4. Keep away from incompatible materials such as strong oxidizing agents, strong bases, and strong acids to prevent decomposition; wash thoroughly after handling .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 1,2-Bis(bromomethyl)benzene is released .
2. Collect 1 2-Bis(bromomethyl)benzene by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 1,2-Bis(bromomethyl)benzene is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and hydrogen bromide .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 1 2-Bis(bromomethyl)benzene may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 1,2-Bis(bromomethyl)benzene due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .