Pamoic Acid CAS 130-85-8

1. Pamoic acid (also known as embonic acid) is a naphthoic acid derivative primarily used as an "inactive" pharmaceutical counterion to form pamoate salts, which prolong the action of active drug ingredients (e.g., in hydroxyzine pamoate, imipramine pamoate, and pyrantel pamoate) by reducing their solubility .
2. Pamoic acid CAS 130-85-8 has been identified as a potent agonist of the orphan G protein-coupled receptor GPR35 (EC50 of 79 nM), activating downstream signaling pathways such as ERK1/2 phosphorylation and β-arrestin2 recruitment, which may contribute to the pharmacological effects of pamoate salts .
3. Pamoic acid exhibits anti-inflammatory properties by inhibiting HMGB1·CXCL12-elicited chemotaxis, reducing leukocyte recruitment (particularly neutrophils) and airway inflammation in murine models of Pseudomonas aeruginosa pneumonia, suggesting potential for treating chronic respiratory diseases .
4. Researchers utilize Pamoic acid CAS 130-85-8 in drug delivery research, where it forms hydrophobic ion-pairs with active pharmaceutical ingredients (APIs) within polymeric nanoparticle cores (e.g., PLA-PEG systems), enabling controlled release kinetics and improved bioavailability of encapsulated drugs .

1. Pamoic acid must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at 2-8°C (refrigerated), protected from light and moisture to maintain stability .
2. Pamoic acid CAS 130-85-8 is classified with GHS signal word "Warning" and hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) according to supplier safety data sheets .
3. Personnel must wear chemical-resistant gloves, tightly fitting safety goggles with side-shields conforming to EN166 (EU) or NIOSH (US), and impervious protective clothing when handling this substance, ensuring adequate ventilation in work areas .
4. Keep away from incompatible Pamoic acid CAS 130-85-8 materials such as strong oxidizing agents; avoid formation of dust and aerosols, prevent contact with skin and eyes, and note that the compound is insoluble in water, ACN, MeOH, and DCM but soluble in DMSO (≥40 mg/mL) and pyridine .

1. Isolate the spill area, ensure adequate ventilation, remove all sources of ignition, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when pamoic acid is released, evacuating personnel to safe areas .
2. Collect Pamoic acid CAS 130-85-8 by sweeping or vacuuming without creating dust using non-sparking tools, or absorb with inert materials such as diatomite or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses as discharge into the environment must be avoided .
4. Dispose of collected Pamoic acid CAS 130-85-8 material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration with flue gas scrubbing; note that the product is not classified as hazardous material for transport (DOT/IATA) .

1. Pamoic acid is combustible with a flash point of 322.4°C and boiling point of 586.2°C at 760 mmHg; under fire conditions, hazardous decomposition products include toxic fumes of carbon monoxide, carbon dioxide, and other irritant gases .
2. Use Pamoic acid CAS 130-85-8 dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as it may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning pamoic acid due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination and pollution .