4-(2-Methylpropyl)acetophenone CAS 38861-78-8

1. 4-(2-Methylpropyl)acetophenone serves as a key pharmaceutical intermediate in the synthesis of the non-steroidal anti-inflammatory drug (NSAID) ibuprofen, where it is a significant intermediate and also appears as an impurity (Impurity E/Impurity C) in ibuprofen manufacturing processes .
2. 4-(2-Methylpropyl)acetophenone CAS 38861-78-8 functions as a versatile organic building block used in the synthesis of various bioactive molecules and pharmaceutical compounds due to its reactive acetophenone moiety .
3. In medicinal chemistry research, it is utilized for the development and quality control of ibuprofen and its related substances, serving as a reference standard for impurity profiling .
4. 4-(2-Methylpropyl)acetophenone CAS 38861-78-8 is employed in organic synthesis reactions, including as a precursor for further functionalization through reactions such as α-bromination, reduction, and condensation due to the presence of both the ketone group and the aromatic ring .

1. 4-(2-Methylpropyl)acetophenone must be stored in a tightly sealed container in a cool, dry, well-ventilated environment, protected from light. Recommended storage conditions include refrigeration at 2-8°C or storage at room temperature under inert atmosphere (nitrogen) . The compound is sensitive to air and light .
2. 4-(2-Methylpropyl)acetophenone CAS 38861-78-8 is classified with GHS hazard statements H315 (Causes skin irritation), H317 (May cause an allergic skin reaction), and H411 (Toxic to aquatic life with long-lasting effects). Hazard codes include Xn (Harmful), N (Dangerous for the environment), and Xi (Irritant). Signal word is "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance. Use adequate ventilation or local exhaust to avoid inhalation of vapors. In case of insufficient ventilation, wear suitable respiratory protection .
4. Keep 4-(2-Methylpropyl)acetophenone CAS 38861-78-8 away from incompatible materials such as strong oxidizing agents and strong bases to prevent decomposition. The compound has a flash point of 54°C (closed cup) and is classified with risk statement R10 (Flammable) . Store separately from ignition sources.

1. Isolate the spill area, eliminate all ignition sources, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable respirator when cleaning up .
2. Collect 4-(2-Methylpropyl)acetophenone CAS 38861-78-8 by absorbing with inert absorbent materials such as sand, vermiculite, or diatomaceous earth using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating splashes or mists during cleanup to prevent skin and eye exposure; prevent the product from entering drains, sewers, or water courses due to environmental toxicity (H411) .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical disposal facilities. The substance has a WGK Germany rating of 3 (highly hazardous to water) .

1. 4-(2-Methylpropyl)acetophenone is classified as flammable with a flash point of 54°C (closed cup). Under fire conditions, the compound decomposes to emit toxic fumes including carbon monoxide and carbon dioxide .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product. Do not use a direct water jet as 4-(2-Methylpropyl)acetophenone CAS 38861-78-8 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus (SCBA) in pressure-demand, NIOSH-approved, and full protective gear when handling fires involving this compound due to hazardous decomposition gases generated during thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination. The product has a boiling point of 268.8°C at 760 mmHg and a vapor pressure of 0.75 Pa at 20°C .