1-(4-Hydroxyphenyl)-1-butanone CAS 1009-11-6

1. 1-(4-Hydroxyphenyl)-1-butanone serves as a versatile organic synthesis building block and pharmaceutical intermediate, particularly in the development of biologically active molecules and medicinal chemistry research .
2. The compound is utilized in material science research, including the synthesis of calixarene derivatives and as a precursor for advanced functional materials .
3. In biochemical research, 1-(4-Hydroxyphenyl)-1-butanone is used as a model compound for studying the anaerobic biodegradation of 4-alkylphenols in environmental samples such as paddy soil microcosms .
4. This compound has been employed in medicinal chemistry for the synthesis and evaluation of potential enzyme inhibitors, including research into inhibitors of 17β-hydroxysteroid dehydrogenase type 3.
5. The presence of both a phenolic hydroxyl group and a ketone functionality makes it a reactive intermediate for various chemical transformations, including esterification, oxidation, and cross-coupling reactions .

1. The product must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment; recommended storage at room temperature in a dry, sealed container away from light .
2. 1-(4-Hydroxyphenyl)-1-butanone is classified with GHS hazard statement H302 (Harmful if swallowed), with signal word "Warning" . It also has risk codes R36/37/38 (Irritating to eyes, respiratory system, and skin) .
3. Personnel must wear chemical-resistant gloves (tested to EN 374 standards), safety goggles with side-shields (conforming to EN 166), and appropriate protective clothing when handling this substance . Avoid generating dust and ensure adequate ventilation in work areas .
4. Keep away from incompatible materials such as strong oxidizing agents to prevent decomposition . Use only non-sparking tools and prevent dust accumulation.

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and dust respirator (N95 or P1 type) when cleaning up .
2. Collect 1-(4-Hydroxyphenyl)-1-butanone by sweeping or vacuuming without creating dust, using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory and eye exposure; prevent the product from entering drains, sewers, or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical disposal facilities .

1. 1-(4-Hydroxyphenyl)-1-butanone is not classified as highly flammable (flash point approximately 131.8°C / 269°F), but may decompose under fire conditions, emitting toxic fumes including carbon monoxide (CO) and carbon dioxide (CO₂) .
2. Use 1-(4-Hydroxyphenyl)-1-butanone dry chemical powder, carbon dioxide, water spray, or alcohol-resistant foam to extinguish fires involving the product .
3. Firefighters should wear self-contained breathing apparatus (SCBA) in pressure-demand, NIOSH-approved, and full protective gear when handling fires involving this compound due to hazardous decomposition gases generated during thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .