Stigmasterol CAS 83-48-7

1. Stigmasterol CAS 83-48-7 is a naturally occurring phytosterol primarily used in research for its cholesterol-lowering properties, where it inhibits cholesterol absorption in the intestines and may help control total cholesterol, HDL, LDL, and TAG levels .
2. Stigmasterol serves as a key precursor for synthetic progesterone and other hormones, and can be transformed easily to progesterone, vitamin D3, and intermediates in the biosynthesis of androgens, estrogens, and corticoids .
3. Stigmasterol exhibits a broad range of biological activities in research, including anti-inflammatory, antioxidant, anticancer, neuroprotective, anti-osteoarthritic, and hypoglycemic effects .
4. Researchers utilize Stigmasterol as a potent in vitro antagonist of farnesoid X receptor (FXR), a DNA polymerase beta inhibitor, and as a cell growth inhibitor with chemopreventive and antimutagenic properties .

1. Stigmasterol CAS 83-48-7 must be stored in a tightly sealed container at -20°C for long-term stability (up to 3 years in powder form), protected from light and heat; storage at 4°C is acceptable for short-term use .
2. Stigmasterol is classified as a moderate to severe irritant to the skin and eyes; it contains a pharmaceutically active ingredient and handling should only be performed by trained personnel familiar with potent active pharmaceutical ingredients .
3. Personnel must wear NIOSH/MSHA-approved respirators, chemical-resistant rubber gloves, and chemical safety goggles with side-shields when handling this substance, ensuring adequate ventilation and avoiding dust and aerosol formation .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases; for solution storage, prepare aliquots and store at -20°C for up to 3 months, avoiding repeated freeze-thaw cycles .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including self-contained breathing apparatus, chemical-resistant gloves, and safety goggles when Stigmasterol CAS 83-48-7 is released .
2. Collect Stigmasterol by sweeping or vacuuming without creating dust using non-sparking tools; for liquid spills, absorb with finely-powdered liquid-binding materials such as diatomite or universal binders .
3. Decontaminate surfaces and equipment by scrubbing with alcohol; avoid creating dust clouds during cleanup to prevent respiratory exposure; keep the product away from drains, water courses, or the soil .
4. Dispose of collected material as hazardous waste according to prevailing country, federal, state, and local environmental regulations; this substance is considered non-hazardous for transport.

1. Stigmasterol CAS 83-48-7 is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides.
2. Use Stigmasterol water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning Stigmasterol due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination and pollution .