4-Nitro-N-methylphthalimide CAS 41663-84-7

1. 4-Nitro-N-methylphthalimide is a key intermediate in the synthesis of novel organosoluble polyimides, where it undergoes nucleophilic aromatic substitution with aromatic diols to form bis(n-methylphthalimide) monomers, which are subsequently hydrolyzed and dehydrated to produce dianhydrides for high-performance polymer applications .
2. 4-Nitro-N-methylphthalimide CAS 41663-84-7 is utilized in the synthesis of 4,4'-oxybis(N-methylphthalimide) and other diaryl ether bisimides via reaction with alkali metal alkylcarboxylate salts (such as potassium acetate or cesium propionate) in dipolar aprotic solvents under substantially anhydrous conditions, achieving yields up to 81% .
3. 4-Nitro-N-methylphthalimide serves as a model compound in enzyme inhibition studies, with documented Ki values of 0.89 μM and 1.1 μM in enzymatic assays for aspartate semialdehyde dehydrogenase, making it useful for inhibitor screening in biochemical research .
4. In materials science, 4-Nitro-N-methylphthalimide is employed as a precursor for the synthesis of phthalocyanine dyes and other functional materials, leveraging its phthalimide core for further chemical modifications .

1. 4-Nitro-N-methylphthalimide must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; long-term storage in a cool, dry place is recommended .
2. 4-Nitro-N-methylphthalimide is classified as an irritant with hazard codes R36/38 (irritating to eyes and skin); personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling 4-Nitro-N-methylphthalimide .
3. 4-Nitro-N-methylphthalimide has a melting point range of 94-98°C (lit.) according to Sigma-Aldrich specifications, while other sources report 177-180°C, indicating potential polymorphic forms or purity differences .
4. 4-Nitro-N-methylphthalimide is slightly hazardous to aquatic life (WGK Germany 3) and should not be discharged directly into drains or water bodies; follow safety statements S26 (eye contact: rinse with water) and S36 (wear suitable protective clothing) when handling this substance .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and a suitable dust respirator when 4-Nitro-N-methylphthalimide is released .
2. Collect 4-Nitro-N-methylphthalimide by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment using appropriate methods, and prevent 4-Nitro-N-methylphthalimide from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations; 4-Nitro-N-methylphthalimide is not classified as hazardous material for transport (DOT/IATA) but requires proper waste management .

1. 4-Nitro-N-methylphthalimide is a combustible solid with a flash point of approximately 172°C (closed cup) and may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use 4-Nitro-N-methylphthalimide water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving 4-Nitro-N-methylphthalimide; do NOT use a direct water jet as it may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 4-Nitro-N-methylphthalimide due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, 4-Nitro-N-methylphthalimide may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination and avoid release into waterways .