6-Fluoroindole CAS 399-51-9

6-Fluoroindole (CAS:399-51-9) is an important organic raw materials.

Its main applications including:

1. 6-Fluoroindole is an important fluoro-substituted indole intermediate for antitumor, antibacterial and neurological drug synthesis.
2. 6-Fluoroindole is a common substrate for Suzuki, Heck and Buchwald coupling reactions in fine organic synthesis.
3. 6-Fluoroindole is applied to manufacture organic optoelectronic materials, fluorescent probes and high-end fine chemical precursors.

1. Keep airtight packaging and store below 25°C in cool dark warehouse to prevent photooxidation of indole skeleton.
2. Minimize repeated opening of packages to avoid discoloration and activity decline caused by air oxidation.
3. Store separately from strong oxidants, concentrated acids and fluorine-sensitive chemical reagents.

1. Avoid inhalation of fine crystalline dust; wear dust mask and chemical-resistant gloves during handling and weighing.
2. Do not ingest the solid; flush contaminated eyes and skin with plenty of running water immediately after exposure.
3. Dispose waste residues and reaction filtrate following fluorinated aromatic hazardous waste disposal standards.

1. The 6-position fluorine atom provides unique electronic effects and improves metabolic stability of indole derivatives.
2. Stable indole heterocyclic structure tolerates moderate heating and conventional catalytic synthesis conditions.
3. High crystal purity effectively lowers by-product formation during bioactive intermediate preparation.