N-Acetyl Carnosine CAS 56353-15-2

1. N-Acetylcarnosine is a naturally occurring dipeptide compound primarily used in ophthalmic research as a prodrug of L-carnosine, where it resists enzymatic hydrolysis by serum carnosinase and delivers L-carnosine to target tissues like the cornea and aqueous humor .
2. N-Acetyl carnosine CAS 56353-15-2 exhibits significant anti-inflammatory, antioxidant, and neuroprotective properties, demonstrating the ability to inhibit LPS-induced nitric oxide synthesis, TNFalpha secretion, and carbonyl formation in microglial cells, suggesting a role in modulating brain inflammation .
3. N-Acetylcarnosine has been clinically investigated in eye drop formulations for the treatment of age-related cataracts, glaucoma, and other ocular disorders associated with oxidative stress, showing efficacy in improving lens transparency and visual function .
4. Researchers utilize N-Acetyl carnosine CAS 56353-15-2 in studies of protein misfolding diseases, as N-acetylcarnosine and related imidazole-containing peptidomimetics act as pharmacological chaperones that can prevent aggregation of crystallin proteins in the lens and protect against UV-induced damage .

1. N-Acetylcarnosine must be stored in a tightly sealed container at -20°C in a dry environment, protected from light and moisture, where it remains stable for up to 3 years .
2. N-Acetyl carnosine CAS 56353-15-2 is classified with GHS signal word "Warning" and hazard statements H302 (Harmful if swallowed), H312 (Harmful in contact with skin), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H332 (Harmful if inhaled), and H335 (May cause respiratory irritation) .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, impervious clothing, and suitable respiratory protection when handling N-acetylcarnosine, ensuring adequate ventilation in work areas and avoiding formation of dust and aerosols .
4. Keep away from incompatible materials such as strong acids/alkalis, strong oxidizing agents, and strong reducing agents to prevent decomposition .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when N-acetylcarnosine is released, evacuating non-essential personnel .
2. Absorb N-Acetyl carnosine CAS 56353-15-2 spills with finely-powdered liquid-binding materials such as diatomite or universal binders; collect solid spills by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol; prevent N-Acetyl carnosine CAS 56353-15-2 from entering drains or water courses as discharge into the environment must be avoided .
4. Dispose of collected material according to local, state, and federal environmental regulations, noting that this substance is considered non-hazardous for transport (DOT, IATA, IMDG) .

1. N-Acetylcarnosine is not classified as highly flammable but may decompose under fire conditions, emitting irritant and potentially toxic fumes .
2. Use N-Acetyl carnosine CAS 56353-15-2 water spray, dry chemical powder, foam, or carbon dioxide fire extinguishers to extinguish fires involving the product .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning N-Acetylcarnosine due to hazardous decomposition gases generated by thermal decomposition .
4. Hazardous decomposition products formed under fire conditions may include toxic fumes; contain fire runoff to prevent environmental contamination and pollution .