2-Methylpyrimidine CAS 5053-43-0

1. 2-Methylpyrimidine serves as a key intermediate and building block in the synthesis of pharmaceutical compounds, including novel pan Bcr-Abl inhibitors for chronic myeloid leukemia research.
2. 2-Methylpyrimidine CAS 5053-43-0 derivatives have been designed using a scaffold-hopping strategy to produce highly potent BCR-ABL kinase inhibitors, with some compounds showing IC50 values as low as 0.13 nM against the wild-type enzyme and activity against the resistant T315I mutant.
3. 2-Methylpyrimidine is employed in organic synthesis for the preparation of various heterocyclic compounds, including quinazolin-4(3H)-one derivatives with potential anticancer activity.
4. Researchers utilize 2-Methylpyrimidine CAS 5053-43-0 as a versatile heterocyclic building block for the synthesis of coordination compounds, silver complexes, and other specialty chemicals for materials science and luminescence studies.

1. 2-Methylpyrimidine must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment under inert gas (nitrogen or argon) to prevent air exposure, with recommended storage at room temperature in a cool, dark place below 15°C.
2. 2-Methylpyrimidine is a flammable liquid with a flash point of 38°C (closed cup) and should be kept away from heat, sparks, open flames, and incompatible materials such as strong oxidizing agents.
3. Personnel 2-Methylpyrimidine CAS 5053-43-0 must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling 2-methylpyrimidine, as it causes skin irritation (H315), serious eye damage (H318), and may cause respiratory irritation (H335).
4. 2-Methylpyrimidine has a boiling point of 132°C and a density of approximately 1.02 g/cm³; containers should be grounded and bonded during transfer to prevent electrostatic discharge, and the product should be stored in a well-ventilated area.

1. Isolate the spill area immediately, ensure adequate ventilation, remove all sources of ignition, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable respiratory protection.
2. Collect 2-Methylpyrimidine CAS 5053-43-0 using non-sparking tools by absorbing with inert materials such as sand, diatomite, or universal binders, and place into suitable closed containers for disposal.
3. Avoid creating vapors or mists during cleanup to prevent respiratory exposure; prevent 2-methylpyrimidine from entering drains, sewers, or water courses.
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations; 2-methylpyrimidine is classified under UN1993 (Flammable Liquid) with packing group III for transport.

1. 2-Methylpyrimidine is a flammable liquid with a flash point of 38°C (closed cup) and may form explosive mixtures with air; vapors are heavier than air and may travel to distant ignition sources.
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving 2-methylpyrimidine; do NOT use a direct water jet as 2-Methylpyrimidine CAS 5053-43-0 may scatter burning material and spread the fire.
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-methylpyrimidine due to hazardous decomposition gases generated by thermal decomposition.
4. During combustion, 2-methylpyrimidine may emit irritant and toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx); contain fire runoff to prevent environmental contamination.