3-Aminopyrazole CAS 1820-80-0

1. 3-Aminopyrazole is a heteroarylamine primarily used as a key building block in the synthesis of heterocyclic compounds of pharmaceutical interest, including symmetrical dialkylpyrazolo[1,5-a]pyrimidines via condensation with symmetrical β-diketones .
2. 3-Aminopyrazole serves as a versatile intermediate in medicinal chemistry for the preparation of pyrazolopyrimidines, 3,4-annelated coumarins, and other bioactive molecules with potential therapeutic applications .
3. 3-Aminopyrazole is employed in the synthesis of kinase inhibitors, including selective leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors, and in the development of non-canonical NF-kB cascade blockers .
4. In research applications, 3-Aminopyrazole is used in the spectroscopic characterization of ferrocenoyl peptides via 1H-NMR spectroscopy and serves as a precursor for generating diverse heterocyclic scaffolds for drug discovery .

1. 3-Aminopyrazole must be stored in a tightly sealed container under inert atmosphere (nitrogen or argon) in a cool, dry, and well-ventilated environment, as it is air and light sensitive .
2. Recommended storage temperature is 2-8°C (refrigerated), protected from light and heat, with long-term stability maintained under these conditions .
3. 3-Aminopyrazole is classified with GHS signal word "Danger" and hazard statements H302 (Harmful if swallowed), H314 (Causes severe skin burns and eye damage), H317 (May cause an allergic skin reaction), and H335 (May cause respiratory irritation) .
4. Personnel must wear chemical-resistant gloves (nitrile rubber), safety goggles with side-shields, face protection, and type P3 (EN 143) respirator cartridges when handling 3-Aminopyrazole, ensuring adequate ventilation in work areas .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 3-Aminopyrazole is released .
2. Collect 3-Aminopyrazole by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol, and prevent 3-Aminopyrazole from entering drains or water courses .
4. Dispose of collected material as hazardous waste according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration; 3-Aminopyrazole is classified under UN 3263 (Corrosive solid, basic, organic, n.o.s.) with packing group II .

1. 3-Aminopyrazole is a combustible solid with a flash point >110°C (230°F) and may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use dry chemical powder, carbon dioxide, alcohol-resistant foam, or water spray to extinguish fires involving the product; do NOT use a direct water jet as 3-Aminopyrazole may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 3-Aminopyrazole due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, 3-Aminopyrazole may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination and avoid release into waterways .