4-iodopyrazole CAS 3469-69-0

1. 4-Iodopyrazole is a key heterocyclic building block used in the synthesis of biologically active compounds, including (pyrazolyl)oxobenzocycloheptapyridinyl acetamides that act as inhibitors of c-Met, a target for anticancer drug development .
2. 4-iodopyrazole CAS 3469-69-0 is employed in the synthesis of heterobiaryls via indium-mediated cross-coupling reactions, enabling the construction of complex molecular architectures for pharmaceutical and material science applications .
3. 4-Iodopyrazole undergoes further iodination in the presence of iodine and ammonium hydroxide to yield 3,4-di-iodo- and 3,4,5-tri-iodo-pyrazole derivatives, expanding its utility as a versatile synthetic precursor .
4. Researchers utilize 4-iodopyrazole in coordination chemistry as a ligand for synthesizing metal complexes, including pyrazole-based remote N-heterocyclic carbene complexes of palladium(II) .

1. 4-Iodopyrazole must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light as it is light-sensitive; recommended storage at room temperature in a cool and dark place below 15°C .
2. 4-iodopyrazole CAS 3469-69-0 is classified with GHS signal word "Warning" and hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation) .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling 4-Iodopyrazole, using a dust mask type N95 (US) or equivalent to avoid inhalation of dust particles .
4. Keep 4-Iodopyrazole away from incompatible materials such as strong oxidizing agents; it is classified as a combustible solid (Storage Class Code 11) with a melting point of 108-110°C .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and a suitable dust respirator when 4-Iodopyrazole is released .
2. Collect 4-iodopyrazole CAS 3469-69-0 by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces using appropriate methods, and prevent 4-Iodopyrazole from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations; 4-Iodopyrazole has a WGK Germany 3 classification (high water hazard potential) .

1. 4-Iodopyrazole is not classified as highly flammable (flash point not applicable) but is a combustible solid that may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving 4-Iodopyrazole; do NOT use a direct water jet as 4-iodopyrazole CAS 3469-69-0 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 4-Iodopyrazole due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, 4-Iodopyrazole may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination and avoid release into waterways .