2-Methylthio-4-pyrimidinol CAS 5751-20-2

1. 2-Methylthio-4-pyrimidinol is a key intermediate in the synthesis of antimetabolite drugs, where the thioether group enhances membrane permeability compared to oxygen analogs while the hydroxyl group enables phosphorylation in kinase recognition .
2. 2-Methylthio-4-pyrimidinol serves as a versatile building block for preparing pyrimidine-based bioactive molecules and heterocyclic compounds in pharmaceutical and agrochemical research .
3. 2-Methylthio-4-pyrimidinol is employed as a certified reference standard for analytical method development, method validation (AMV), and quality control (QC) applications in pharmaceutical manufacturing .
4. 2-Methylthio-4-pyrimidinol (also known as S-Methyl-2-thiouracil) is utilized in metabolic stability studies, particularly for identifying sulfur oxidation metabolites .

1. 2-Methylthio-4-pyrimidinol must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light, with recommended storage at room temperature in a cool and dark place below 15°C .
2. 2-Methylthio-4-pyrimidinol is stable under recommended storage conditions and has a melting point of 200-204°C .
3. 2-Methylthio-4-pyrimidinol is classified with GHS signal word "Danger" and hazard statements H302 (Harmful if swallowed), H315 (Causes skin irritation), H318 (Causes serious eye damage), and H335 (May cause respiratory irritation) .
4. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 2-Methylthio-4-pyrimidinol is released .
2. Collect 2-Methylthio-4-pyrimidinol by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent 2-Methylthio-4-pyrimidinol from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 2-Methylthio-4-pyrimidinol is a combustible solid that may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and sulfur oxides .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 2-Methylthio-4-pyrimidinol may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 2-Methylthio-4-pyrimidinol due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, 2-Methylthio-4-pyrimidinol may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination and avoid release into waterways .