4-Amino-3-fluorophenol CAS 399-95-1

1. 4-Amino-3-fluorophenol is a key intermediate in the synthesis of pharmaceutical compounds, particularly in the preparation of drugs targeting neurological disorders and cancer .
2. 4-Amino-3-fluorophenol serves as a versatile building block in organic synthesis for the preparation of heterocyclic compounds, including benzoxazoles, benzothiazoles, and other nitrogen-containing heterocycles .
3. 4-Amino-3-fluorophenol is employed in the synthesis of agrochemicals, dyes, and specialty chemicals, where its fluorine and amino groups enable selective functionalization .
4. Researchers utilize 4-Amino-3-fluorophenol as a reference standard in analytical chemistry and as a starting material for the preparation of various biologically active molecules with potential antimicrobial and anti-inflammatory properties .

1. 4-Amino-3-fluorophenol must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from light and moisture; recommended storage at 2-8°C or at -20°C for long-term stability .
2. 4-Amino-3-fluorophenol is classified with GHS hazard statements H302 (Harmful if swallowed), H312 (Harmful in contact with skin), H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H332 (Harmful if inhaled), with signal word "Warning" .
3. Personnel must wear chemical-resistant gloves, safety goggles with side-shields, and protective clothing when handling this substance, ensuring adequate ventilation in work areas .
4. Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; wash thoroughly after handling .

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator when 4-Amino-3-fluorophenol is released .
2. Collect 4-Amino-3-fluorophenol by sweeping or vacuuming without creating dust using non-sparking tools, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses .
4. Dispose of collected material according to local, state, and federal environmental regulations through licensed chemical destruction or controlled incineration .

1. 4-Amino-3-fluorophenol is not classified as highly flammable but may decompose under fire conditions, emitting toxic fumes including carbon monoxide, carbon dioxide, nitrogen oxides (NOx), and hydrogen fluoride .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as 4-Amino-3-fluorophenol may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 4-Amino-3-fluorophenol due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination .