3-Hydroxypyridine CAS 109-00-2

1. 3-Hydroxypyridine is widely utilized as a key intermediate in pharmaceutical synthesis, particularly for producing cholinergic drugs like benzipyrinium bromide, pyridostigmine bromide, and pirbuterol, as well as in the development of anticancer agents like 2-amino-3-hydroxypyridine.
2. 3-Hydroxypyridine CAS 109-00-2 serves as a versatile building block in agrochemical formulations for synthesizing 2-chloro-3-hydroxypyridine used in herbicides and other crop protection agents.
3. In cosmetic applications, 3-hydroxypyridine derivatives are used in oxidative hair dye systems and are investigated for potential anti-aging and antioxidant skincare formulations.
4. Researchers utilize 3-Hydroxypyridine CAS 109-00-2 as a reagent in analytical chemistry for detecting and quantifying metal ions, in corrosion inhibitor development, and in biochemical assays studying enzyme activity and metabolic pathways.

1. 3-Hydroxypyridine must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment at room temperature (RT) or at -20°C for long-term stability; solutions should be stored at -80°C for up to 6 months or -20°C for 1 month.
2. 3-Hydroxypyridine CAS 109-00-2 is classified with GHS hazard statements H315 (Causes skin irritation), H319 (Causes serious eye irritation), and H335 (May cause respiratory irritation), with signal word "Warning".
3. Personnel must wear chemical-resistant nitrile rubber gloves (minimum 0.11 mm thickness tested to EN 374), safety goggles with side-shields conforming to EN166, and impervious clothing when handling this substance, ensuring adequate ventilation and avoiding formation of dust and aerosols.
4. Keep 3-Hydroxypyridine CAS 109-00-2 away from incompatible materials such as strong oxidizing agents to prevent decomposition; do not let product enter drains; for solution storage, prepare aliquots and avoid repeated freeze-thaw cycles, using within 1 month at -20°C or 6 months at -80°C.

1. Isolate the spill area, ensure adequate ventilation, and wear full personal protective equipment including chemical-resistant gloves, safety goggles, and suitable dust respirator (type N95 or P1 filter) when 3-Hydroxypyridine is released.
2. Collect 3-Hydroxypyridine CAS 109-00-2 by sweeping or vacuuming without creating dust using non-sparking tools, or absorb with inert materials, and place into suitable closed containers for disposal.
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; prevent the product from entering drains or water courses.
4. Dispose of collected material by dissolving or mixing with combustible solvent and burning in a chemical incinerator equipped with an afterburner and scrubber, according to local, state, and federal environmental regulations.

1. 3-Hydroxypyridine is combustible with NFPA fire rating of 1 (materials that require considerable preheating before ignition), flash point of 173°C, melting point of 123-130°C, and boiling point of 151-153°C at 4 hPa.
2. Use water spray, alcohol-resistant foam, dry chemical powder, or carbon dioxide to extinguish fires involving the product; do NOT use a direct water jet as 3-Hydroxypyridine CAS 109-00-2 may scatter burning material.
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 3-Hydroxypyridine due to hazardous decomposition gases generated by thermal decomposition.
4. Hazardous decomposition products formed under fire conditions include toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides (NOx); during combustion, may emit irritant and toxic fumes; contain fire runoff to prevent environmental contamination.