4-Dimethylaminopyridine / DMAP CAS 1122-58-3

1. 4-Dimethylaminopyridine (DMAP) is a nucleophilic catalyst widely used in organic synthesis for acylation, silylation, and esterification reactions, significantly accelerating the reaction rate of tertiary amines .
2. DMAP CAS 1122-58-3 serves as a catalyst in peptide coupling reactions, in the synthesis of organic carbonates and carbamates, and as an acyl transfer reagent in the preparation of esters from sterically hindered alcohols .
3. 4-Dimethylaminopyridine is employed in the synthesis of pharmaceutical intermediates, including anti-inflammatory drugs (such as the 1-naphthyl ester of thiazolium salt), and in the hydrolysis of dinitrophenyl and t-butoxycarbonyl amino acids .
4. In polymer chemistry, DMAP is used as a catalyst for the synthesis of polyurethanes and as a curing agent for epoxy resins, and it can be immobilized on insoluble polymers for use in the synthesis of oligonucleotides and carbonates .

1. 4-Dimethylaminopyridine must be stored in a tightly sealed container in a cool, dry, and well-ventilated environment, protected from moisture and light, with recommended storage at 2-8°C or at room temperature in a cool, dark place below 15°C .
2. DMAP CAS 1122-58-3 is classified with GHS hazard statements H301 (Toxic if swallowed), H311 (Toxic in contact with skin), H315 (Causes skin irritation), H319 (Causes serious eye irritation), H331 (Toxic if inhaled), and H335 (May cause respiratory irritation), with signal word "Danger" .
3. Personnel must wear chemical-resistant gloves (nitrile rubber, minimum 0.11 mm thickness), tightly fitting safety goggles with side-shields, face protection, and protective clothing when handling this substance, ensuring adequate ventilation in work areas .
4. Keep DMAP CAS 1122-58-3 away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases to prevent decomposition; wash thoroughly after handling and avoid release to the environment .

1. Isolate the spill area, ensure adequate ventilation, remove all sources of ignition, and wear full personal protective equipment including self-contained breathing apparatus when 4-Dimethylaminopyridine is released .
2. For DMAP CAS 1122-58-3 small spills, sweep or vacuum the material without creating dust using non-sparking tools; for larger spills, cover with inert absorbent materials such as sand, diatomite, or universal binders, and place into suitable closed containers for disposal .
3. Avoid creating dust clouds during cleanup to prevent respiratory exposure; decontaminate surfaces and equipment by scrubbing with alcohol .
4. Prevent DMAP CAS 1122-58-3 from entering drains, water courses, or the soil; dispose of collected material as hazardous waste according to local, state, and federal environmental regulations, noting UN2811 classification for toxic solids .

1. 4-Dimethylaminopyridine is combustible with a flash point of 154.8°C and NFPA fire rating of 1 (materials that require considerable preheating before ignition); under fire conditions, hazardous decomposition products include toxic fumes of carbon monoxide, carbon dioxide, and nitrogen oxides (NOx) .
2. Use water spray, dry chemical powder, carbon dioxide, or alcohol-resistant foam to extinguish fires involving the product; do NOT use a direct water jet as DMAP CAS 1122-58-3 may scatter burning material .
3. Firefighters should wear self-contained breathing apparatus in pressure-demand, MSHA/NIOSH approved, and full protective gear when handling burning 4-Dimethylaminopyridine due to hazardous decomposition gases generated by thermal decomposition .
4. During combustion, may emit irritant and toxic fumes; move containers from the fire area if safe to do so, cool exposed containers with water spray from a protected location, and contain fire runoff to prevent environmental contamination .