4-Bromoaniline CAS 106-40-1

1. 4-Bromoaniline is primarily used as a key precursor in the production of azo dyes and dihydroquinazolines . 4-Bromoaniline CAS 106-40-1 also serves as a carbon and nitrogen supplement in specialized culture media .
2. The compound functions as a versatile building block in the synthesis of pharmaceuticals, agrochemicals, and organic compounds . 4-Bromoaniline CAS 106-40-1 is employed in cross-coupling reactions such as Suzuki, Buchwald-Hartwig, and Heck to introduce diverse functional groups .
3. Applications of 4-Bromoaniline also include its use in the preparation of para-bromobiphenyl through the Gomberg-Bachmann reaction and as a versatile intermediate in medicinal chemistry and material science .

1. Store 4-Bromoaniline in a tightly sealed container under an inert atmosphere (argon/nitrogen) in a cool, dry, well-ventilated place, as it is light and air sensitive . Recommended storage is in a cool, dark place at 2-8°C or below 15°C .
2. Keep 4-Bromoaniline strictly away from strong oxidizing agents, acids, acid chlorides, acid anhydrides, and chloroformates due to incompatibility . It reacts with acids and strong oxidants .
3. Always use 4-Bromoaniline CAS 106-40-1 appropriate personal protective equipment (PPE) including chemical-resistant gloves, safety goggles, and protective clothing; avoid dust formation and ensure adequate ventilation when handling 4-Bromoaniline .

1. Immediately isolate the spill area (at least 25 meters/75 feet for solids) and contain 4-Bromoaniline using dry, inert, non-combustible absorbent material . Sweep into covered containers, moistening first to prevent dusting .
2. One recommended procedure involves dampening spilled 4-Bromoaniline with 60-70% ethanol and transferring the dampened material to a suitable container, sealing all contaminated items in vapor-tight plastic bags . Prevent entry into drains or waterways .
3. Personnel must wear full chemical-protective equipment including particulate filter respirator or self-contained breathing apparatus (SCBA) during cleanup . 4-Bromoaniline CAS 106-40-1 is classified for transport (UN2811, Hazard Class 6.1, PG III) and requires hazardous waste disposal according to local, state, and federal environmental regulations .

1. 4-Bromoaniline is classified with GHS signal word "Danger" . It is harmful if swallowed (H302), harmful if inhaled (H332), and harmful if absorbed through the skin (H311/H312) . 4-Bromoaniline CAS 106-40-1 causes skin irritation (H315) and serious eye irritation (H319) .
2. 4-Bromoaniline causes methemoglobinemia, leading to symptoms including blue lips/fingernails/skin, headache, dizziness, confusion, and labored breathing .4-Bromoaniline CAS 106-40-1 may cause damage to organs (H373) . It is very toxic to aquatic life with long-lasting effects (H400/H410) .
3. 4-Bromoaniline is combustible (flash point >110°C) . Thermal decomposition or combustion produces toxic and corrosive fumes including hydrogen bromide and nitrogen oxides . Always consult the specific Safety Data Sheet (SDS) for 4-Bromoaniline for complete hazard information and first-aid procedures (P305+P351+P338 for eyes, P302+P352 for skin, P301+P312+P330 for ingestion, P304+P340 for inhalation) .